May 27: Wayne State University discontinued its women’s ice hockey program. School officials declared the decision was necessary as a result of continuing reductions in the state of Michigan appropriations towards higher education.
June 13: Mercyhurst Lakers assistant coach Paul Colontino has left the club to become head coach of the Robert Morris Colonials. He is the third head coach in Colonials history, after the resignation of Nate Handrahan, who left to assume the head coaching position at Ohio State.
Sept. 6: Robert DeGregorio, Commissioner for College Hockey America (CHA), announced that the Penn State Nittany Lions have been accepted into the CHA. The Nittany Lions will officially join the conference starting with the 2012-13 season. 
September 17, 2011: Senior Bailey Bram registered a hat trick to go with her three assists, as the Lakers trounced the Wilfrid Laurier Golden Hawks women's ice hockey program by a 10-2 tally. Her sister, Shelby Bram scored one goal while freshman Kristine Grenier also registered a hat trick in the match. Kelley Steadman contributed with four assists.
September 24, 2011: Sophomore Christine Bestland notched five points as the Lakers defeated the Stoney Creek Jr. Sabres of the PWHL by a 6-0 score. The Lakers scored four goals within a five and a half minute time span late in the second period.
September 25, 2011: Freshman Caroline Luczak notched a goal, while registering three assists as the Lakers defeated the Toronto Jr. Aeros of the PWHL.
In the Mercyhurst Lakers season opener on September 30, 2011, Bestland was named the game's First Star in a 4-0 shutout over the nationally ranked Quinnipiac Bobcats. Bailey Bram scored the game winning goal (it was the 61st goal of her career). Goaltender Hillary Pattenden earned her 13th career shutout (and 81st career win) while Bailey Bram scored the game winning goal.
October 1, 2011: Bailey Bram played in her 100th career game for the Mercyhurst Lakers. Bram would be held pointless as the Lakers would lose the game by a 1-0 tally to Quinnipiac. It was Quinnipiac's first victory over Mercyhurst in twelve regular season matches.
October 7-8: Robert Morris freshman Katie Fergus accumulated three points in her NCAA debut with one goal and two assists. Against the Lindenwood Lions, she got her first-collegiate point fewer than nine minutes into the opening period. Later in the game, she scored her fist goal as the Colonials were on the penalty kill. In the second game versus Lindenwood, she earned her first multi-goal game. Fergus became one of just two freshmen in Colonials history to register multi-point performances in the first two games of a season. Fergus finished the series versus Lindenwood by scoring three goals and two assists five points. In addition, she had eight shots to complement a +5 plus/minus.
October 8, 2011: Brianna Delaney registered the sixth three-point game of her career at Robert Morris. With the achievement, she tied the Colonials all-time record for career points. The 24th-career multi-point game of her career increased her point total to 97. The total now equals the record that Sara O'Malley set during the 2010-11 campaign. 
October 27-28: The series versus the Lindenwood Lady Lions ice hockey program marked the first time that Lindenwood hosted an NCAA Division I opponent in their home arena. Mercyhurst would win the October 28 match by a 7-0 tally, in which Lakers freshman Shelby Bram would score her first career NCAA goal. The October 29 contest saw Mercyhurst emerge as the victor in a 14-0 whitewash.Kelley Steadman would score four goals and notch an assist, while Jess Jones would earn a hat trick. The Bram sisters (Shelby and Bailey) each earned two goals.
December 9: In a 4-2 loss to the Boston College Eagles on December 9, 2011, Kelley Steadman scored her 100th career point. The point was a goal in the second period on Boston College goalkeeper Corrine Boyles.
December 10: In a 3-2 overtime victory versus Boston College, Hillary Pattenden made a career high 48 saves to earn the 91st victory of her NCAA career, tying former Wisconsin goaltender Jessie Vetter for the NCAA Division I record. Jill Szandzik scored at 3:01 into overtime for her second goal of the season. Bailey Bram had three assists, including one on the game-winner to give her 40 points in 16 games. Christine Bestland also earned three points. Pattenden’s 48 saves broke her previous high of 38 (made earlier in the 2011-12 season) at Minnesota State-Mankato.
December 14: In a 9-0 defeat of the Lindenwood Lady Lions, Hillary Pattenden broke Jessie Vetter's record for career NCAA wins, by notching her 92nd career victory. Forward Bailey Bram scored two goals and added four assists while Kelley Steadman scored the game winning goal.