This is a list of Great Lakes Junior Hockey League Standings for the 1980-81 season.
- The Wayne Chiefs and the Fraser Highlanders folded (a team called the Fraser Flags would join the league for the 1981-82 season)
Based on the league standings it is unclear when these two teams actually folded.
Team GP W L T OTL GF GA P Paddock Pool Saints 53 39 10 4 - 357 223 82 Redford Royals 53 38 13 2 - 337 212 78 Detroit Jr. Wings 54 35 16 3 - 395 244 73
As to why these standings are irregular is unknown. It is possible that a pair of teams may have folded. or the teams played non-league games that were included in the standings.
The Paddock Pool Saints won fifth straight Robertson Cup.