The 1945-46 Central Ottawa Valley League champion was Cornwall. They participated in the 1945-46 Ottawa District Senior Playoffs. They beat Hull & District League champion the Hull Volants in the first round, two games to one. They beat North Stomont League champion Chesterville in the second round in a best of three series. They beat Little Nation League champion Thurso in the quarterfinals, two games to one. They beat Lower Ottawa Valley League champion the Buckingham Abbotts in the semifinals, two games to none (4-3, 5-3). They lost in the final round to the Upper Ottawa Valley League champion Pembroke Lumber Kings, two games to none (13-1, 11-5).
No further information is available on teams or standings.